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In this study, we utilize cutting-edge single-cell multi-omics approaches to decipher the molecular mechanisms underlying cardiac regeneration in zebrafish. Our findings reveal a previously uncharacterized population of cardiac progenitor cells that orchestrate the regenerative response.

We report the development of CRISPR-engineered T cells designed to target a specific neoantigen commonly expressed in recurrent glioblastoma. In a phase I clinical trial, this approach demonstrated promising safety and efficacy profiles in patients who had failed standard therapies.

We present a novel graph neural network architecture for predicting drug-target interactions with high accuracy. By integrating molecular structure data with protein sequence information, our approach outperforms existing methods on benchmark datasets and successfully identifies novel therapeutic candidates for challenging targets.

This study provides the most comprehensive map to date of the developing human brain connectome using high-resolution 7T MRI. Our longitudinal analysis reveals critical periods of network formation and pruning that correlate with cognitive milestone achievement.

We demonstrate that targeted modulation of specific gut microbiota can significantly enhance patient response to immune checkpoint inhibitor therapy in advanced melanoma. This randomized clinical trial identifies key bacterial species and metabolites that mediate this effect.

Using cutting-edge spatial transcriptomics, we characterize the complex tumor microenvironment in pancreatic ductal adenocarcinoma. We identify distinct cellular neighborhoods that contribute to therapy resistance and metastatic potential, providing new targets for intervention.